A neural mechanism that controls vacillation behavior during pain-reward motivational conflict.
(Science Advances, 2021)
The ‘decapitation’ of primary cilia drives cell cycle re-entry.
(Cell, 2017)
Timelapse imaging of calcium signals in primary cilia under fluid flow, as revealed by cilia-targeted ratiometric calcium indicator.
(Nature Methods, 2013)
Research Articles
(lab members underlined; *co-firsts; #co-correspondence)
Jia, S., Phua, S.C., Nihongaki, Y., Li, Y., Pacella, M., Li, Y., Mohammad, A.M., Sun, S., Inoue, T., Schulman, R. Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells. Nature Communications 2021; 12(5279).
Phua, S.C.#, Tan, Y.L.#, Kok, A.M.Y., Senol, E., Chiam, C.J.H., Lee, C.Y., Peng, Y., Lim, A.T.J., Mohammad, H., Lim, J.X., Fu, Y#. A distinct parabrachial to lateral hypothalamus circuit for motivational suppression of feeding by nociception. Science Advances 2021; 7(19), eabe4323. (Highlighted in A*STAR Research).
Phua S.C.#, Chiba S., Suzuki M., Su E., Roberson E.C., Pusapati G.V., Setou M., Rohatgi R., Reiter J.F., Ikegami K.#, Inoue T.# Dynamic remodeling of membrane composition drives cell cycle through primary cilia excision. Cell 2017; 168(1-2), 264-279.
Garcia-Gonzalo F.R.*, Phua S.C.*, Roberson E.C., Garcia III G., Abedin M., Schurmans S., Inoue T., Reiter J.F. Ciliary phosphoinositides modulate Hedgehog signaling. Developmental Cell 2015; 34(4), 400-409.
Su S.*, Phua S.C.*, DeRose R., Chiba S., Narita K., Kalugin P.N., Katada T., Kontani K., Takeda S., and Inoue T. Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nature Methods 2013; 10(11), 1105-1107.
Lin Y.C., Niewiadomski P., Lin B., Nakamura H., Phua S.C., Jiao J., Levchenko A., Inoue T., Rohatgi R., Inoue T. Chemically-inducible diffusion trap reveals molecular sieve-like barrier at primary cilia. Nature Chemical Biology 2013; 9(7), 437–443.
Phua S.C., Pohlmeyer C., Inoue T. Rapidly relocating molecules between organelles to manipulate small GTPase activity. ACS Chemical Biology 2012; 7(12): 1950-1955.
Schumacher K.M., Phua S.C., Schumacher A., Ying J.Y. Controlled formation of biological tubule systems in extracellular matrix gels in vitro. Kidney International 2008; 73(10): 1187–1192.
Review Articles
Phua, S.C.*, Nihongaki, Y.*, & Inoue, T. Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides. Current Opinion in Cell Biology 2018; 50, 72–78.
Phua S.C.#, Lin Y.C., Inoue T#. An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli. Cell Calcium 2015; 58(4), 415-422.
Lin Y.C., Phua S.C., Lin B., and Inoue T. Visualizing molecular diffusion through passive permeability barriers in cells: conventional and novel approaches. Current Opinion in Chemical Biology 2013; 17(4), 663-671.
Book Chapters
Lai F.P.L., Mutalif R.A., Phua S.C., Stewart C.L. Informatics-based analysis of mechanosignaling in the laminopathies. Methods in Cell Biology 2010; 98(C): 323-335.
Patents
Schulman R.S., Jia S., Phua S.C., Nihongaki Y., Li Y., Pacella M., Mohammed A.M., Sun S.X., Inoue T. Growth and site-specific organization of micro-scale bimolecular devices on living cells. US Patent App. 18/003,462, 2023.